BEHAVIOR OF SOLVENT-EXPOSED HYDROPHOBIC GROOVE IN THE ANTI-APOPTOTIC BCL-XL PROTEIN: CLUES FOR ITS ABILITY TO BIND DIVERSE BH3 LIGANDS FROM MD SIMULATIONS.

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis.Its overexpression in many human cancers makes it an important target for anti-cancer drugs.Bcl-XL interacts Products with the BH3 domain of several pro-apoptotic Bcl-2 partners.This helical bundle protein has a pronounced hydrophobic groove

Abstract Dendritic cells (DC) are the initiators and modulators of the immune responses.Some species of pathogenic microorganisms have developed immune evasion strategies by controlling antigen presentation function of DC.Simian virus 40 (SV40) is a DNA tumor virus of rhesus monkey origin.It can induce cell transformation and tumorigenesis in many

A new Technical Standard that supports the clearance of materials and equipment (personal property) from U.S.Department of Energy (DOE) accelerator facilities has been developed.The Standard Bottle Lamp Gift Box focuses on personal property that has the potential to be radiologically impacted by accelerator operations.It addresses material clearanc

Abstract Background Delimiting cryptic species in elasmobranchs is a major challenge in modern taxonomy due the lack of available phenotypic features.Employing stand-alone genetics in splitting a cryptic species may prove problematic for further studies and for implementing conservation management.In this study, we examined mitochondrial DNA and ge

Objective: To compare frequency of Hyperprolactinemia with Risperidone and Olanzapine Clutch Component in patients with first episode psychosis.Study Design: Randomized controlled trial.Place and Duration of Study: Combined Military Hospital (CMH) Lahore, over a period of six months from Sep 2015 to Feb 2016.Subjects and Methods: Total 60 patients